Trial reportEuropean journal of nutrition2026
Effect of two types of time-restricted eating on glycemic, lipid indices, and weight in women with polycystic ovary syndrome: a randomized controlled trial.
Trial report in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePolycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder among women of reproductive age with significant metabolic impairments. Time-restricted eating (TRE) has emerged as a promising dietary strategy for improving metabolic health. Although both early time-restricted eating (eTRE) and mid-day time-restricted eating (mTRE) have shown beneficial metabolic effects, their comparative efficacy in women with PCOS remains unclear. This study aimed to directly compare the effects of eTRE and mTRE on glycemic control, lipid profiles, and anthropometric outcomes in women with PCOS.
methodsIn this 6-week randomized controlled trial, 75 women with PCOS were allocated to one of three groups: eTRE (8:00 AM-6:00 PM), mTRE (11:00 AM-9:00 PM), or a control group with ad libitum eating. The primary outcome was fasting insulin level. Secondary outcomes included FBS, insulin resistance indices, lipid profile (total cholesterol (TC), LDL-C, HDL-C, and TG), body weight, BMI, waist circumference (WC), and dietary intake. Metabolic and anthropometric variables were assessed at baseline and post-intervention, while dietary intake was evaluated at baseline, mid-intervention, and study completion.
resultsBoth eTRE and mTRE significantly reduced FBS, fasting insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), body weight, and WC compared with the control group (P < 0.05). Additionally, eTRE significantly improved TC (P < 0.001) and LDL-C levels (P = 0.01), whereas similar changes were not observed in the mTRE group.
conclusionTRE, particularly eTRE, appears to be an effective dietary intervention for women with PCOS, offering significant benefits for glycemic control, metabolic health, and weight management.
trial registrationIRCT20221122056575N1.
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