Evidence map›Paper›PMID 42371096›Full record

ArticleJournal of gastroenterology2026

Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan.

Tetsuya Takikawa, Yoichi Kakuta, Kazuhiro Kikuta, Serina Haruyama, Ami Kawamoto, Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroshi Nagai, Takanori Sano, Mikihiro Fujiya and 25 more

Abstract read
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In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Tetsuya TakikawaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan. tetsuya.takikawa.c2@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-6214-7337
Yoichi KakutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Kazuhiro KikutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Serina HaruyamaInflammatory Bowel Disease Center, Yokohama City University Medical Center, Kanagawa, Japan.
Ami KawamotoDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Shinichiro ShinzakiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Katsuyoshi MatsuokaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
Hiroshi NagaiDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Takanori SanoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Mikihiro FujiyaDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.
Takuto SaikiDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masanao NakamuraDepartment of Endoscopy, Nagoya University Hospital, Aichi, Japan.
Atsushi NishidaDepartment of Gastroenterology, Shiga University of Medical Science, Shiga, Japan.
Sakiko HiraokaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Takayuki MatsumotoDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, School of Medicine, Iwate Medical University, Iwate, Japan.
Katsuya EndoDepartment of Gastroenterology, Tohoku Medical and Pharmaceutical University, Miyagi, Japan.
Kazuyuki NarimatsuDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, National Defense Medical College, Saitama, Japan.
Shojiro YamamotoDepartment of Internal Medicine, Faculty of Medicine, Division of Gastroenterology and Hepatology, University of Miyazaki, Miyazaki, Japan.
Takashi KagayaDepartment of Gastroenterology, NHO Kanazawa Medical Center, Ishikawa, Japan.
Shin-Ichiro HagiwaraDepartment of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.
Noritaka TakatsuInflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Hiroshi NakaseDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Kazuichi OkazakiDepartment of Internal Medicine, Kansai Medical University Kori Hospital, Neyagawa, Osaka, Japan.
Yoki FurutaDepartment of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tetsu KinjoDepartment of Endoscopy, University of the Ryukyus Hospital, Okinawa, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hirotake SakurabaDepartment of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Takashi TashiroDepartment of Internal Medicine, Division of Gastroenterology, Aichi Medical University School of Medicine, Aichi, Japan.
Makoto NaganumaDivision of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Fukunori KinjoCenter for Gastroenterology, Urasoe General Hospital, Okinawa, Japan.
Tomohisa TakagiMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tadakazu HisamatsuDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.
Mitsuhiro KawanoDepartment of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Japan Pancreatitis Study Group

Funding

Ministry of Health, Labour and Welfare 23FC1015Ministry of Health, Labour and Welfare 23FC1027
6 · The paper itself

Abstract

backgroundPatients with inflammatory bowel disease (IBD) are at increased risk of acute pancreatitis (AP). However, the clinical characteristics of AP in IBD and the differences between ulcerative colitis (UC) and Crohn's disease (CD) remain unclear.

methodsWe conducted a nationwide, multicenter, retrospective study at 28 institutions in Japan. Patients ≥ 16 years with UC or CD treated between 2012 and 2021 were included. We assessed the characteristics of AP in IBD, including differences between UC and CD. We also compared UC and CD patients with and without AP.

resultsAmong 24,849 patients with IBD (16,233 UC and 8,616 CD), 342 (1.4%) developed AP. Among these AP cases, severe AP and mortality were observed in 7.6% and 0.6%, respectively. Drug-induced AP was the most common etiology (55.6%), and autoimmune pancreatitis (AIP) ranked third (10.8%). Compared with UC, CD patients with AP had higher rates of intensive care unit admission (P = 0.002) and severe AP (P = 0.003). CD (odds ratio, 2.96; P = 0.02) and drug-induced or AIP etiology (odds ratio, 0.19; P < 0.001) were associated with severe AP. UC patients with AP had higher rates of pancolitis (P < 0.001), extraintestinal manifestations (P = 0.001), and steroid dependence (P = 0.006) than those without AP.

conclusionsAP in IBD showed distinct clinical characteristics compared with AP in the general population. CD patients may develop more severe AP than UC, whereas UC patients with AP may have more aggressive and/or refractory disease features compared with those without AP.

Indexed as

Acute pancreatitisCrohn’s diseaseExtraintestinal manifestationsInflammatory bowel diseaseUlcerative colitis

Identifiers

PMID42371096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.