Trial reportEuropean journal of applied physiology2026
Bypassing the systemic cardiorespiratory threshold: neuromuscular electrical stimulation elicits a SPARC response through accelerated glycolytic flux.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
5 authors.
Funding
Abstract
backgroundSecreted protein acidic and rich in cysteine (SPARC) is a myokine with potential tumor-suppressive properties. SPARC secretion typically requires vigorous-intensity exercise. Neuromuscular electrical stimulation (NMES) non-selectively recruits glycolytic Type II muscle fibers, potentially inducing intense localized metabolic stress despite a low systemic cardiorespiratory demand. PURPOSE: This study aimed to investigate the acute effects of a single bout of NMES at an intensity corresponding to the first ventilatory threshold (VT
methodsThirteen healthy men (21.0 ± 0.7 years) participated in a randomized crossover study: Control (rest) and 30 min NMES at the maximum tolerable intensity with a heart rate (HR) ceiling 120% of VT
resultsNMES significantly increased serum SPARC (616.0 ± 200.9 to 739.2 ± 279.8 ng/mL, p = 0.0078, d = 0.61) and blood lactate (1.4 ± 0.4 to 4.8 ± 1.5 mmol/L, p < 0.0001, d = 8.42) levels while reducing glucose levels (p = 0.0377, d = - 0.92). The correlation between Δ SPARC and Δ Lactate (r = 0.37, p = 0.21) showed a positive trend consistent with the effect size observed in a previous high-intensity exercise study.
conclusionNMES at VT
trial registrationUMIN-CTR (UMIN000060258).
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