Trial reportEuropean journal of applied physiology2026
Acute neuromuscular and metabolic responses to a novel low-load combined isometric and isotonic resistance training protocol.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
purposeThis study investigated the acute physiological responses to a novel combined resistance training (CB) protocol-integrating isometric pre-exhaustion with low-load, high-velocity, short-arc isotonic contractions-and compared them with low-intensity slow training (LST) and high-load (HL) training.
methodsForty-eight healthy men were randomly assigned to one of three groups: LST (50% one-repetition maximum [1RM], slow tempo), HL (80% 1RM, normal tempo), or CB (40% 1RM; a 20-s isometric contraction followed by eight high-velocity, short-arc repetitions). Surface electromyography (EMG) and near-infrared spectroscopy (NIRS) of the vastus lateralis, alongside serum IGF-1 concentrations, were assessed during and following three leg-press sets.
resultsDespite utilizing a 40% 1RM load, the CB protocol elicited mean EMG amplitudes significantly greater than LST during the final set (p = 0.009, g = 1.23). NIRS analysis demonstrated a significantly lower change in tissue oxygen saturation (ΔStO
conclusionBy concurrently demanding high neural drive and inducing profound metabolic stress, the time-efficient CB protocol provides a robust physiological stimulus despite minimal mechanical loading. This approach serves as a practical, joint-friendly alternative for populations necessitating reduced mechanical stress. TRIAL REGISTRATION NUMBER: UMIN-CTR (UMIN000060486).
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