Evidence map›Paper›PMID 42371038›Full record

ArticleCellular and molecular life sciences : CMLS2026

PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.

Jianbo Cao, Zixuan He, Weitai Chai, Meng Tian, Tianyan Wei, Xiu Liu, Yue Wang, Shuang Liu, Ruitong Liu, Yue Yin and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jianbo CaoKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Zixuan HeKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Weitai ChaiKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Meng TianKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Tianyan WeiKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Xiu LiuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Yue WangKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Shuang LiuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Ruitong LiuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Yue YinKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Yajun WangKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Tong LiuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Zheng LiangDepartment of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, 130033, China.
Songyan LiuDepartment of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, 130033, China.
Shilai BaoInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Huali YuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China.
Xiaoxiao HeKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China. hexx100@nenu.edu.cn.
Xiaojuan ZhuKey Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin, 130024, China. zhuxj720@nenu.edu.cn.

Funding

Science and Technology Department of Jilin Province YDZJ202501ZYTS321STI2030-Brain Science and Brain-Like Intelligence Technology 2021ZD020400 2021ZD0204003
6 · The paper itself

Abstract

Epigenetic regulation of neuronal calcium signaling during postnatal cortical development is critical for voluntary movement. Protein arginine methyltransferase 5 (PRMT5) acts as an epigenetic regulator that is involved in movement disorders, yet its underlying mechanism remains poorly understood. Here, we report that conditional knockout of Prmt5 in excitatory neurons (cKO

Indexed as

CalciumCalcium Channels, L-TypeProtein-Arginine N-MethyltransferasesAnimalsEpigenesis, GeneticHistonesHomeostasisMiceMice, KnockoutNeuronsPromoter Regions, GeneticCalciumCalcium Channels, L-TypeHistonesPrmt5 protein, mouseProtein-Arginine N-MethyltransferasesCav1.3Epigenetic regulationHistone methylationMovement disorder

Identifiers

PMID42371038
PMCPMC13582763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.