Evidence map›Paper›PMID 42371027›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Lens epithelial cell damage and reduced aquaporin-1 immunoreactivity in liquefied mature cataracts.

Kosuke Ichihara, Koji Komatsu, Yoichiro Masuda, Atsushi Tohma, Masanobu Iida, Ai Iwauchi, Hoshiho Kubota, Yosuke Nakazawa, Naoki Yamamoto, Masayuki Shimoda and 1 more

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kosuke Ichihara *Department of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
Koji Komatsu *Department of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
Yoichiro MasudaDepartment of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan. ymasuda@jikei.ac.jp.
Atsushi TohmaDepartment of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
Masanobu IidaDepartment of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
Ai IwauchiDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Hoshiho KubotaDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Yosuke NakazawaFaculty of Pharmacy, Keio University, Minato-ku, Tokyo, 105-8512, Japan.
Naoki YamamotoResearch Promotion Headquarters, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
Masayuki ShimodaDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.

Funding

Japan Society for the Promotion of Science JP25K20212
6 · The paper itself

Abstract

purposeTo investigate the pathological characteristics of lens epithelial cells (LECs) in liquefied versus non-liquefied mature cataracts.

methodsTwenty-one unilateral and one bilateral mature cataract cases underwent surgery. Based on intraoperative findings, eyes were classified into a liquefied (11 eyes) and non-liquefied (11 eyes) groups. Patient history, ocular morphology, and histopathological evaluation of the anterior lens capsule were analyzed. Cross-sectional and flat-mounted LEC specimens were examined using upright microscope (UM), and aquaporin-1 (AQP1) immunostaining was assessed via confocal laser scanning microscope (CLSM).

resultsUM showed extensive LEC nuclear deficiency/flattening in all liquefied cases and a higher prevalence of subcapsular fibrosis (82% vs. 9%) compared with the non-liquefied group. CLSM revealed significantly lower AQP1 immunostaining scores in the liquefied group compared to the non-liquefied group (1.76 ± 0.59 vs. 4.48 ± 0.60, p = 0.00054). In this small cohort, atopic dermatitis was present in 5 of 11 eyes (45.5%) in the liquefied group, whereas diabetes mellitus was present in 4 of 11 eyes (36.4%) in the non-liquefied group. Given the uneven distribution of these systemic backgrounds, disease-specific differences in LEC nuclear deficiency/flattening, subcapsular fibrosis, and AQP1 immunostaining could not be assessed separately.

conclusionsLens liquefaction in mature cataracts was associated with a marked paucity of identifiable LECs and lower AQP1 immunostaining scores. The potential roles of these epithelial changes in lens liquefaction warrant further study.

Indexed as

Aquaporin-1Intumescent white cataractLens epithelial cellsLens liquefactionMature cataract

Identifiers

PMID42371027

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