ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026
Intracranial vasomotor and blood flow responses to light-intensity aerobic exercise in young adults: a 4D flow MRI study.
M Erin Moir, Anna J Howery, Alma Spahic, Adam T Corkery, Paul F Baumhardt, Yasmine Coovadia, Nicole A Loggie, Sarean Harmoni A Sumner, Laura B Eisenmenger, Marlowe W Eldridge and 3 more
Abstract read
In one paragraphArticle in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
M Erin MoirBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-3027-4964 Anna J HoweryBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Alma SpahicDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
Adam T CorkeryBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-1657-3025 Paul F BaumhardtBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Yasmine CoovadiaBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0009-0008-5727-9918 Nicole A LoggieBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Sarean Harmoni A SumnerBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-3151-2039 Laura B EisenmengerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0001-6764-4239 Marlowe W EldridgeDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0003-3636-1679 Kevin M JohnsonDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
Oliver WiebenDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0002-7931-1930 Jill N BarnesBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-6317-4153 Funding
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6MNon-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal AgingR01AG082208 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Laura Burns Eisenmenger · 2024 to 2026
$2.2MImpact of cerebral anatomical variations on cerebral perfusion, cerebrovascular reactivity, and biomarkers of cognitive declineR01NS117746 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BARNES, JILL NICOLE · 2024 to 2024
$508kHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL007936NHLBI NIH HHS T32 HL007936NIA NIH HHS R01 AG082208NINDS NIH HHS R01 NS117746Virginia Horne Henry Research GrantWisconsin Alumni Research Foundation (WARF)
6 · The paper itselfAbstract
Aerobic exercise elicits an increase in cerebral blood flow. This finding is evidenced by augmented internal carotid artery (ICA) and vertebral artery (VA) blood flow measured extracranially and supported by an increase in intracranial blood velocity (e.g., middle cerebral artery, MCA). To date, no studies have quantified intracranial blood flow or vessel cross-sectional area (CSA) during exercise, given challenges in combining aerobic exercise with magnetic resonance imaging (MRI) approaches. The present study leveraged an MRI-compatible exercise device and novel 4D flow MRI sequences that are less sensitive to motion artifacts to evaluate vasomotor and blood flow responses during aerobic exercise and to explore the influence of biological sex. Thirty-four young adults (18 females, 31 ± 5 yr of age) completed supine exercise at 30% V̇o
Indexed as
Cerebrovascular CirculationExerciseVasomotor SystemAdultBlood Flow VelocityCarotid Artery, InternalFemaleHumansMagnetic Resonance ImagingMaleMiddle Cerebral ArteryRegional Blood FlowVasodilationVertebral ArteryYoung Adult4D flow MRIcerebral blood flowexercise
Identifiers
PMID42370989
PMCPMC13412120
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