ArticleCEN case reports2026
Nephrin-IgG co-localization expression in pediatric steroid-resistant nephrotic syndrome: a case series from Indonesia.
Article in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Steroid-resistant nephrotic syndrome (SRNS) remains a major clinical challenge due to its heterogeneous etiologies and poor response to conventional immunosuppressive therapy. Anti-nephrin IgG has been associated with podocyte injury and proteinuria, suggesting a potential pathogenic role in SRNS. This case series was conducted to present real-world data on the evaluation of nephrin-IgG immunofluorescence colocalization in pediatric SRNS in a low-resource setting, and to examine whether this approach may inform treatment selection in routine clinical practice. We describe four pediatric patients with SRNS who underwent kidney biopsy following persistent proteinuria despite immunosuppressive therapy. Case 1 showed severe hypoalbuminemia and anasarca with preserved renal function after full dose steroid; Case 2 remained edematous with nephrotic range proteinuria after seven cycle of cyclophosphamide; Case 3 progressed to chronic kidney disease despite cyclophosphamide and mycophenolate mofetil; Case 4 had normal kidney function and no edema, despite steroid resistant. Nephrin-IgG co-localization was observed in all cases. Clinical outcomes were heterogeneous, and assessment of treatment response was limited by resource constraints and loss to follow-up. These findings are exploratory in nature and suggest the potential applicability of nephrin-IgG co-localization in a low-resource setting, warranting further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.