Evidence map›Paper›PMID 42370696›Full record

ArticleMicrobiology spectrum2026

Arginine-substituted Mastoparan-C derivatives combat dual bacterial pathogens:

Luyao Zhang, Anqi Huang, Mingyu Lu, Jingjing Wang, Yingyu Wang, Fei Mo, Mingchun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luyao Zhang *College of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Anqi Huang *College of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Mingyu LuCollege of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Jingjing WangCollege of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Yingyu WangCollege of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Fei MoCollege of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.ORCID 0009-0000-4125-9930
Mingchun LiuCollege of Animal Science and Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.

Funding

China Postdoctoral Science Foundation 2024M762161Liaoning Provincial Science and Technology Program Joint Project 2024-BSLH-270Liaoning Provincial Science and Technology Program Joint Project 2025-BS-0524
6 · The paper itself

Abstract

The synergistic interactions in multi-pathogen infections compromise wound healing and limit therapeutic efficacy. In this study, we designed and synthesized arginine-substituted derivatives of the antimicrobial peptide Mastoparan-C (MP-C). Among them, Arg²MP-C and Arg IMPORTANCE: Wounds infected with multiple bacterial species are notoriously difficult to treat, often leading to poor healing and limited effectiveness of existing therapies. In this study, we developed new antimicrobial peptides by introducing arginine substitutions into a natural peptide called Mastoparan-C. Two of our engineered peptides, Arg²MP-C and Arg

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesArginineCoinfectionPeptidesWasp VenomsWound InfectionAnimalsDisease Models, AnimalEscherichia coliEscherichia coli InfectionsFemaleHumansIntercellular Signaling Peptides and ProteinsMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesArginineIntercellular Signaling Peptides and ProteinsmastoparanPeptidesWasp Venomsantimicrobial peptidesarginine modificationmembrane disruptionstructure-activity relationshipwound polymicrobial infection

Identifiers

PMID42370696
PMCPMC13436381

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.