Observational studyEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2026
Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.
Daniele Faccenda, Marco Bergonti, Tom De Potter, Michel Haïssaguerre, Johan Saenen, Carlo De Asmundis, Giuseppe Ciconte, Marta De Riva, Michela Casella, Jacopo Costantino and 33 more
Abstract readMulticenter StudyObservational Study
In one paragraphObservational study in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
43 authors.
Daniele FaccendaCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0009-0007-5159-2500 Marco BergontiCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0000-0001-9864-1938 Michel HaïssaguerreHôpital Cardiologique du Haut-Lévêque, CHU Bordeaux, L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.ORCID 0000-0001-7644-6146 Carlo De AsmundisHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.ORCID 0000-0001-9351-0760 Giuseppe CiconteArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, Milano, Italy.ORCID 0000-0001-7886-5467 Michela CasellaCardiology and Arrhythmology Clinic, University Hospital 'Ospedali Riuniti', Ancona, Italy.ORCID 0000-0002-5322-1742 Jacopo CostantinoDepartment of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0009-0000-4869-4898 Mikael LaredoInstitut de Cardiologie, Hôpital Universitaire Pitié-Salpêtriere, AP-HP, Sorbonne Université, Paris, France.ORCID 0000-0002-7326-2656 Avi SabbagThe Davidai Center for Rhythm Disturbances and Pacing, Chaim Sheba Medical Center, Tel Hashomer and the Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.ORCID 0000-0003-4295-6679 Matteo AnselminoDivision of Cardiology, Cardiovascular and Thoracic Department, Città Della Salute e Della Scienza di Torino Hospital, Turin - Department of Medical Sciences, University of Turin, Turin, Italy.ORCID 0000-0002-6311-4270 Andrea RossiArrhythmology Division, Fondazione Gabriele Monasterio CNR-Regione Toscana, via Giuseppe Moruzzi, Pisa, Italy.ORCID 0000-0003-4430-6821 Matteo BertiniDepartment of Translational Medicine, Cardiology Unit, Sant'Anna University Hospital, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-5285-7140 Lia CrottiDepartment of Cardiology, IRCCS, Istituto Auxologico Italiano, San Luca Hospital, Cardiomyopathy Unit, Milan, Italy.ORCID 0000-0001-8739-6527 Christian-Hendrik HeegerDepartment of Rhythmology, Cardiology and Internal Medicine, Asklepios Klinik Hamburg Altona Hamburg, Hamburg, Germany.ORCID 0000-0002-9014-8097 Claudio TondoDepartment of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy.ORCID 0000-0002-8500-8313 Elena ArbeloArrhythmia Section, Cardiology Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0003-0424-6393 Moises LevinsteinDepartment of Electrophysiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Sebastiaan R D PiersDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-5463-6384 Maria L CaputoCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0000-0003-1190-5967 Carlo PapponeArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, Milano, Italy.ORCID 0000-0002-0901-6135 Domenico G Della RoccaHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.ORCID 0000-0003-3837-3462 Paolo CompagnucciCardiology and Arrhythmology Clinic, University Hospital 'Ospedali Riuniti', Ancona, Italy.ORCID 0000-0003-1924-6548 Tardu ÖzkartalCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0000-0001-8391-8164 Raffaele SalernoArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, Milano, Italy.ORCID 0009-0009-8433-692X Chiara PavoneInstitut de Cardiologie, Hôpital Universitaire Pitié-Salpêtriere, AP-HP, Sorbonne Université, Paris, France.ORCID 0000-0002-6837-6800 Valeria RellaDepartment of Cardiology, IRCCS, Istituto Auxologico Italiano, San Luca Hospital, Cardiomyopathy Unit, Milan, Italy.ORCID 0000-0001-8485-3649 Lorenzo GigliCardiac Arrhythmia Department, Great Metropolitan Hospital Niguarda, Milan, Italy.
Cristina BallaDepartment of Translational Medicine, Cardiology Unit, Sant'Anna University Hospital, University of Ferrara, Ferrara, Italy.ORCID 0000-0003-2110-8961 Cristina ChimentiDepartment of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-5954-3796 Nicolas JohnerHôpital Cardiologique du Haut-Lévêque, CHU Bordeaux, L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.ORCID 0000-0001-8236-1165 Alessandro LascheraCardiovascular Center, AZORG Hospital, Aalst, Belgium.
Manuela AveraimoCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.
Esther ScheirlynckCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0000-0002-3816-2166 Marco SchiavoneDepartment of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy.ORCID 0000-0003-0720-3380 Cinzia MonacoHôpital Cardiologique du Haut-Lévêque, CHU Bordeaux, L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Université Bordeaux, Bordeaux, France.ORCID 0000-0002-5373-1689 Giulio ConteCardiology Department, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, Lugano CH-6900, Switzerland.ORCID 0000-0003-2248-3456 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
aimsAtrial fibrillation (AF) is highly prevalent among cardiac amyloidosis (CA) patients and contributes significantly to their morbidity and mortality. Evidence regarding AF ablation efficacy and safety in CA patients remains limited. The aim of our study is to evaluate baseline characteristics, clinical course and outcomes of AF ablation in a series of patients with transthyretin (ATTR) or light-chain (AL) CA from a multicentre international registry. METHODS AND
resultsPatients with CA who underwent AF ablation were included. Co-primary endpoints were: (i) atrial arrhythmia (AA) recurrence; (ii) a composite endpoint of all-cause mortality and heart failure hospitalization (HFH). 109 patients (mean age 72.4 ± 7.4 years, females 17.4%, persistent AF 64.2%, ATTR 78%, AL 22%) were included. Radiofrequency, cryo-balloon and pulsed-field ablation were performed in 67%, 15% and 18% of patients, respectively; 49.5% received pulmonary vein isolation plus additional ablations. Low voltage zones were documented in 34 out of 44 patients undergoing electro-anatomical mapping (77.3%). During a median follow-up of 22.7 months, 63 patients (58.3%) experienced AA recurrence (32.4% persistent AF recurrence), with no significant differences between CA subtypes (ATTR 59.5% vs. AL 54.2%, log-rank P = 0.55). The composite endpoint of HFH and all-cause death occurred in 27 patients (25%). Recurrence of persistent AF was associated with three-fold higher risk (OR 2.9, P = 0.02) of the composite endpoint.
conclusionCA patients undergoing AF ablation present high prevalence of persistent AF. Freedom from AA after AF ablation is achieved in 42% of patients after a two-year follow-up. Patients with persistent AF recurrence have a three-fold higher risk of HFH and death.
Indexed as
Amyloid Neuropathies, FamilialAtrial FibrillationCardiomyopathiesCatheter AblationImmunoglobulin Light-chain AmyloidosisPulmonary VeinsAgedFemaleHumansMaleRecurrenceRegistriesRisk FactorsTime FactorsTreatment OutcomeAblationAtrial fibrillationCardiac amyloidosisPulmonary vein isolation
Identifiers
PMID42370609
PMCPMC13312283
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