ArticleJournal of cytology
Usefulness of Cytokeratin Fragment Antigen 21-1 Estimation in Fine-Needle Aspiration Washout Specimens in Diagnosis of Axillary Breast Cancer Metastasis.
Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: Fine-needle aspiration biopsy (FNAB) is a valuable technique for diagnosing axillary breast cancer metastasis. However, its sensitivity can sometimes be affected by sampling errors and technical artifacts. Aim: We examined whether cytokeratin fragment antigen 21-1 (CYFRA) estimation by manual enzyme-linked immunosorbent assay (ELISA) on FNAB needle washouts could add diagnostic information to FNAB. Materials and Methods: This cross-sectional study involved FNAB from 138 lymph nodes in 108 suspected breast cancer patients. Papanicolaou and May-Grünwald-Giemsa smears were prepared for cytological examination. CYFRA was estimated by manual ELISA from fine-needle washouts after smear preparation. A cut-off of 1.93 ng/mL was considered to be a positive test for CYFRA. Results: The CYFRA estimates were significantly associated with the FNAB results ( Conclusion: CYFRA estimation by manual ELISA is a simple and accurate test which supplements and enhances the diagnostic usefulness of axillary FNAB in suspected breast cancer metastasis.
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