Evidence map›Paper›PMID 42370290›Full record

ArticleResearch square2026

Precision RNAi for Fibrodysplasia Ossificans Progressiva: a combinatorial, unimolecular, allele selective approach.

Yeon-Suk Yang, Katherine Y Gross, David Cooper, Sachin Chaugule, Mi-Jeong Kim, Christopher Dahlke, Emma Mayer, Eric M Kercher, Ji Woong Kim, Thomas Ormsby and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yeon-Suk YangDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Katherine Y GrossRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
David CooperRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-1356-1707
Sachin ChauguleDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Mi-Jeong KimDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Christopher DahlkeRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
Emma MayerDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Eric M KercherDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, 01605, USA.
Ji Woong KimDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Thomas OrmsbyRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-4371-5316
Nozomi YamadaRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
Jillian CaiazziRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-7077-2116
Samuel O JacksonRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
Mohamad Omar RachidRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
Dimas EchiverriaRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.
Hassan H FakihRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-7598-0993
Ken YamadaRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-5714-8298
Francis Y LeeDepartment of Orthopaedics and Rehabilitation, Yale University; New Haven, Connecticut, 06510, USA.ORCID 0000-0003-2275-2441
Anastasia KhvorovaRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0001-6928-8071
Julia F AltermanRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-6195-0857
Jae-Hyuck ShimDepartment of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-4947-3293

Funding

Novel approaches to promote healing of bone loss in inflammatory arthritisR01AR078230 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Ellen M Gravallese, Jae-Hyuck Shim · 2022 to 2026
$2.6M
Development of a long-lasting, bone-targeted gene therapy for osteogenesis imperfectaR01AR086572 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jae-Hyuck Shim · 2025 to 2026
$1.3M
BD FACSAriaTM Fusion Fluoresence-Activated Cell SorterS10OD028576 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHRADER, CAROL E · 2020 to 2020
$565k
Precision Gene Editing on Osteogenesis ImperfectaR21AR084644 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SATO, TADATOSHI, SHIM, JAE-HYUCK · 2024 to 2025
$387k
NIAMS NIH HHS R01 AR078230NIAMS NIH HHS R01 AR086572NIAMS NIH HHS R21 AR084644NIH HHS S10 OD028576
6 · The paper itself

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder caused by a dominant mutation in the

Identifiers

PMID42370290
PMCPMC13308366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.