ArticleResearch square2026
Infection dose shapes granuloma phenotypes in a humanized mouse model of tuberculosis.
Shashi Prakash Singh, Preena Prasanna, Vinay Shivanna, Donna Perry, Edward J Dick, David F Ackart, Brendan K Podell, Riti Sharan
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Shashi Prakash SinghTexas Biomedical Research Institute.
Preena PrasannaKerala Veterinary and Animal Sciences University.
Vinay ShivannaTexas Biomedical Research Institute.
Donna PerryTexas Biomedical Research Institute.
Edward J DickTexas Biomedical Research Institute.
David F AckartColorado State University.
Brendan K PodellColorado State University.
Riti SharanTexas Biomedical Research Institute.
Funding
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MTexas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P · 2021 to 2025
$8.3MInterdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9MSingle cell trancriptomics to identify LTBI reactivation markers in TB/HIV co-infectionR21AI170148 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2022 to 2023
$800kEffect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infectionR56AI184089 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2024 to 2024
$719kCharacterizing IL-22 driven chronic immune activation in HIV/TB co-pandemicK01OD031898 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2021 to 2023
$567kSignificant upgrade and expansion of the Southwest National Primate Research Center Pathology UnitS10OD028732 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KAUSHAL, DEEPAK · 2020 to 2020
$489kDual Beckman Coulter DxH 690T and Beckman Coulter DxH 560 ALS10OD032443 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TURNER, JOANNE · 2022 to 2022
$86kNIAID NIH HHS P30 AI161943NIAID NIH HHS P30 AI168439NIAID NIH HHS R21 AI170148NIAID NIH HHS R56 AI184089NIH HHS K01 OD031898NIH HHS P51 OD011133NIH HHS S10 OD028732NIH HHS S10 OD032443
6 · The paper itselfAbstract
Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, yet current murine models fail to fully recapitulate human granuloma biology. Here, we utilized hCD34 + NCG humanized mice (humouse) to investigate how infection dose shapes granuloma formation and disease progression following aerosol infection with
Indexed as
granulomahumanized miceimmune cell recruitmentinflammationInterleukin-10Tuberculosis
Identifiers
PMID42370250
PMCPMC13308376
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