Evidence map›Paper›PMID 42370248›Full record

ArticleResearch square2026

Cytochrome P450-catalyzed hydroxylation of Δ8-tetrahydrocannabinol and implications for pharmacogenetics.

Mengqi Zhao, Philip Lazarus

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mengqi ZhaoDivision of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14215, USA.
Philip LazarusDivision of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14215, USA.

Funding

Gene-tobacco carcinogen interactions and lung cancer risk - a novel approach for precision cancer preventionR01CA269223 · NCI · WASHINGTON STATE UNIVERSITY · PI Philip Lazarus, Jian-Min Yuan · 2023 to 2026
$2.6M
NCI NIH HHS R01 CA269223
6 · The paper itself

Abstract

The use of Δ8-tetrahydrocannabinol (Δ8-THC) has become increasingly prevalent in the United States but its metabolic pathways remain poorly characterized. This study aimed to identify the key enzymes responsible for the 11'-hydroxylation of Δ8-THC, its primary metabolic pathway, and assess the effect of metabolizing enzyme genotype on this activity. The intrinsic clearance of recombinant (r) CYP2C9 was >6,200-fold higher than that observed for rCYP2C19, the only other tested CYP450 with detectable activity against Δ8-THC. The

Indexed as

cannabinoidCYP2C19CYP2C9CYP450THC

Identifiers

PMID42370248
PMCPMC13308419

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.