ArticleResearch square2026
Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance.
Yousin Suh, Jiping Yang, Xifan Wang, HyeRim Han, Yizhou Zhu, Lei Zhang, Haiqi Chen, Paul Robbins
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Jiping YangColumbia University Medical Center.
Xifan WangColumbia University Medical Center.
Yizhou ZhuColumbia University Medical Center.
Haiqi ChenColumbia University Medical Center.
Funding
THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1MCombinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's DiseaseR01AG057706 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGE, FRED H, GLASS, CHRISTOPHER K · 2017 to 2021
$8.1MResilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2MSystems Modeling of Alzheimers Disease in C. elegansRF1AG057341 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MURPHY, COLEEN TARA, SUH, YOUSIN · 2017 to 2017
$3.7MA stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionR01HL150521 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2020 to 2023
$2.7MHuman tissue specific age-related gene expression changes, their genetic regulations and the link to human diseasesR01AG055501 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TU, ZHIDONG · 2018 to 2022
$2.2MFrom in vivo to in vitro heterochronic parabiosis to identify geronic factorsR01AG057433 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RANDO, THOMAS A., SUH, YOUSIN · 2017 to 2020
$2.1MThe Aging vs Disease Trajectory Trees of CNS Cell Types Based on Simultaneous Single Nuclear Global Genomic AnalysesR01AG061521 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G, SUH, YOUSIN · 2019 to 2021
$2.1MRegulatory Landscape of the Aging Human OvaryR01AG069750 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROSENFELD, MICHAEL G, SUH, YOUSIN · 2020 to 2024
$1.7MNHLBI NIH HHS R01 HL150521NIA NIH HHS P01 AG017242NIA NIH HHS R01 AG055501NIA NIH HHS R01 AG057433NIA NIH HHS R01 AG057706NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061521NIA NIH HHS R01 AG069750NIA NIH HHS RF1 AG057341
6 · The paper itselfAbstract
Centenarians represent a natural model of delayed human aging, offering a unique opportunity to uncover genetic mechanisms that promote longevity. However, the functional consequences of the genetics variants carried by these long-lived individuals remain poorly characterized in physiologically relevant systems. Here, we introduced two linked missense variants in
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PMID42370242
PMCPMC13308375
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