ArticleTheranostics2026
Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers.
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
Rationale: Cervical lymph node metastases in oral cancer patients are a frequent occurrence and important prognostic factor. Anatomical and molecular imaging modalities can identify neck metastases with varying sensitivity and specificity but perform poorly in clinically negative neck nodes with microscopic disease. Herein we investigate the use of porphyrin-lipid nanotheranostics (PS) for multimodal detection of neck disease in preclinical models of oral cancer. Methods: Xenograft models of tongue cancer were established in nude rats using MOC2 mouse oral squamous cells. PS nanoparticles were radiolabelled with positron-emitting Copper-64 ( Results: The tongue tumour model yielded micrometastases to 54% of neck nodes by 14 d post-implantation. Following IT injection, sentinel and metastatic lymph nodes were visible with Conclusions: Nanotheranostic
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