ArticleFrontiers in oncology2026
Postoperative radiotherapy-induced pulmonary leiomyosarcoma in breast cancer: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Radiation-induced sarcoma (RIS) is a rare and severe complication of radiotherapy following breast cancer surgery. It is characterized by a long latency period, high malignancy, limited clinical experience in diagnosis and treatment, and substantial individual variation in prognosis. This study reports a case of radiation-related pulmonary leiomyosarcoma that developed more than 20 years after radiotherapy for breast cancer. The tumor harbored a TP53 mutation and showed low PD-L1 expression. Imaging documented rapid tumor progression over a short interval, which rendered radical resection impossible and complicated efforts to improve quality of life. However, the patient attempted to receive multiple treatments-interventional therapy, chemotherapy, targeted therapy, and immunotherapy-but the response was poor, survival was under 10 months, and the patient ultimately died.
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