ArticleEULAR rheumatology open2026
Chondrocalcinosis and the haemochromatosis-linked
Article in EULAR rheumatology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Objectives: C282Y genetic homozygosity is the main cause of the iron-overload disorder haemochromatosis. Musculoskeletal pain and arthropathy are common in haemochromatosis, but less is known about chondrocalcinosis (cartilage calcification) with the C282Y variant, especially in the community. We assessed knee chondrocalcinosis in intelligent dual-energy X-ray absorptiometer (iDXA) images from UK Biobank volunteers by Methods: Data were from 236 European genetic ancestry C282Y homozygotes and 236 age, sex, and body mass index (BMI)-matched controls with no C282Y alleles (48-80 years, mean 64.6, SD ±7.6). Of 472 participants, 435 had relevant left and right knee iDXA imaging. Evidence of chondrocalcinosis was assessed by an experienced reporting radiographer blind to genotype to ensure unbiased and objective evaluation. Logistic regression models were age, sex, and BMI matched. Results: C282Y homozygotes had significantly increased odds of knee chondrocalcinosis (odds ratio [OR]: 3.79, 95% CI: 1.51-9.55, Conclusions: In this community-genotyped sample, male C282Y homozygotes had markedly increased odds of knee chondrocalcinosis. Evaluation of serum ferritin levels to identify possible haemochromatosis may be justified in knee chondrocalcinosis management.
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