ArticlePNAS nexus2026
Dual phosphoregulatory mechanisms of condensin I revealed by biochemical reconstitution.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Exactly how cell cycle regulators control sequential large-scale transformations of chromatin structure during mitosis is not fully understood. Here, through biochemical reconstitution with a minimal set of recombinant proteins, we demonstrate that the assembly and disassembly of mitotic chromatids are orchestrated by dual modes of phosphoregulation of condensin I. First, cyclin B-Cdk1 phosphorylates the terminal intrinsically disordered regions (tIDRs) of the non-structural maintenance of chromosome subunits, releasing condensin I from self-suppression imposed by these regions. Second, phosphorylation of a conserved residue in the central region of the kleisin subunit CAP-H by Cdk1 is essential for the full activation of condensin I. Conversely, addition of the protein phosphatase PP2A-B55 is sufficient to trigger the dissociation of condensin I from reconstituted chromatids, thereby driving their disassembly. Complementary analyses using
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