Evidence map›Paper›PMID 42369803›Full record

ArticleHeart rhythm O22026

Circulating metabolomic profile and its association with atrial fibrillation and systemic inflammation.

Udit Thakur, William Figgett, Devy Deliyanti, Joshua Hawson, Robert Anderson, David Chieng, Sarah Kummerfeld, Peter M Kistler, Alex McLellan, Geoffrey Lee and 4 more

Abstract read
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In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Udit ThakurDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
William FiggettGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Devy DeliyantiDepartment of Anatomy and Physiology, University of Melbourne, Victoria, Australia.
Joshua HawsonDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Robert AndersonDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
David ChiengHeart Centre, Alfred Hospital, Melbourne, Victoria, Australia.
Sarah KummerfeldGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Peter M KistlerDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Alex McLellanDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Geoffrey LeeDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Fabienne MackayQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stephen JosephDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Jonathan M KalmanDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Ahmed Al-KaiseyDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with chronic inflammation and metabolic dysregulation. Metabolic and inflammatory pathways may influence atrial electrophysiology and structural remodeling, contributing to AF onset and persistence, yet key circulating signatures remain poorly defined. Objective: The purpose of this study was to characterize systemic inflammatory markers and circulating metabolomic profiles in patients with paroxysmal and persistent AF compared with non-AF controls. Methods: In this prospective study, 101 patients were enrolled (mean age 59.9 ± 14.7 years; 73/101 [72%] male), including 41 with paroxysmal AF, 30 with persistent AF, and 30 controls. Fasting plasma samples were analyzed using targeted gas chromatography-mass spectrometry to quantify 156 metabolites and multiplex flow cytometry to profile 13 inflammatory cytokines. Results: Interleukin-18 (IL-18) concentrations were significantly elevated in patients with AF compared with controls ( Conclusion: This study identifies distinct metabolic and inflammatory signatures in AF, with IL-18 and specific energy-related metabolites emerging as potential markers of disease phenotype. These hypothesis-generating findings warrant validation in larger cohorts.

Indexed as

Atrial fibrillationCirculating metabolomic profileInflammatory markersInterleukin-18Medium-chain fatty acidsMetabolomics

Identifiers

PMID42369803
PMCPMC13307494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.