ArticleTherapeutic advances in medical oncology2026
Homologous recombination deficiency correlates with tumor-infiltrating lymphocytes and predicts patient outcomes in hormone receptor-positive/HER2-negative breast cancer.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer represents the most prevalent molecular subtype but demonstrates pronounced biological and clinical heterogeneity. Homologous recombination deficiency (HRD) and tumor-infiltrating lymphocytes (TILs) have recently emerged as key determinants of prognosis and immune activity, but their interplay in this subtype remains understudied. Objectives: To assess the relationship between HRD, TILs, and clinical outcomes in HR+/HER2- breast cancer and validate the prognostic value of HRD. Design: Retrospective multicenter cohort study. Methods: A total of 365 patients (332 with available TILs data) from three institutions were enrolled. HRD was quantified using Shallow HRD algorithm on low-depth whole-genome sequencing (threshold: score ⩾6). TILs were evaluated by the MD Anderson system (⩾10% classified as high). Spearman correlation, Kaplan-Meier survival analysis, and multivariable Cox regression were performed. Results: HRD scores were inversely correlated with TILs (Spearman rho = -0.13, Conclusion: HRD represents a reliable independent prognostic biomarker in HR+/HER2- breast cancer in this cohort, with an inverse association with TILs suggesting immune evasion. Its potential impact on prognosis and treatment requires further validation in prospective clinical trials.
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