ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[Active Oxygen Influences Foam Macrophage Formation by Regulating Peroxisome Proliferator-Activated Receptor-γ Expression].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the effect of reactive oxygen species (ROS) on foam macrophage formation by regulating the expression of peroxisome proliferator-activated receptor-γ (PPARγ). Methods: From June 2018 to December 2021, human blood samples were obtained from 30 healthy donors, and peripheral blood mononuclear cells (PBMCs) were isolated. The PBMCs were differentiated into human monocyte-derived macrophages (HMDMs) and subsequently infected with Mycobacterium tuberculosis H37Ra strain to establish an in vitro human macrophage infection model. ROS production was modulated using N-acetylcysteine (NAC) and emodin, while PPARγ activity was regulated using the PPARγ agonist (BRL49653) or antagonist (GW9662). The effects of H37Ra infection on intracellular ROS production and lipid formation in macrophages, as well as the impact of ROS generation on foam macrophage formation, were assessed using 2', 7'-dichlorodihydrofluorescein diacetate (DCFH2-DA) and Oil Red O staining. The influence of ROS production on PPARγ expression in macrophages was examined by qRT-PCR and Western blot. Furthermore, the involvement of PPARγ activity in ROS-mediated regulation of foam macrophage formation was investigated by modulating PPARγ activity. Results: The results of Oil Red O staining and DCFH2-DA detection showed that, compared with the control group, H37Ra infection promoted ROS production in HMDMs and induced foam cell formation, with statistically significant differences ( Conclusion: ROS can promote the formation of foam macrophages by downregulating the expression of PPARγ.
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