SynthesisFrontiers in microbiology2026
Prevalence and outcomes of central line-associated bloodstream infections in intensive care units in Saudi Arabia: a systematic review and meta-analysis.
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Central line-associated bloodstream infections (CLABSIs) are among the most serious healthcare-associated infections in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare burden. However, evidence regarding the epidemiology and outcomes of CLABSI in Saudi Arabian ICUs remains limited. This systematic review and meta-analysis aimed to evaluate the incidence, microbiology, and clinical outcomes of CLABSI among ICU patients in Saudi Arabia. Methods: A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines. PubMed, Medline, Embase, and Web of Science were searched for studies published between January 2015 and November 2025. Studies conducted in Saudi Arabian ICUs reporting CLABSI incidence, microbiology, or clinical outcomes were included. Pooled incidence rates were estimated using random-effects meta-analysis. The review protocol was prospectively registered in PROSPERO (CRD420261337969). Results: Of 2,788 identified records, 11 studies were included in the systematic review and 7 in the meta-analysis. Included studies primarily consisted of retrospective observational, surveillance, and cohort studies conducted across different ICU settings in Saudi Arabia. The pooled CLABSI incidence was 3.05 per 1,000 central line-days (95% CI: 1.85-4.26; Conclusion: CLABSI remains a significant healthcare-associated infection among ICU patients in Saudi Arabia and is associated with considerable clinical burden. Variability in incidence across ICU settings highlights the importance of strengthening infection prevention strategies and surveillance systems. Further multicenter studies are needed to improve understanding of risk factors, microbiological patterns, and preventive interventions.
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