Evidence map›Paper›PMID 42369495›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adults.

Michelle Y Li, Paulina Tolosa-Tort, Margo B Heston, Philip S Insel, Shea J Andrews

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle Y LiDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.
Paulina Tolosa-TortDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.
Margo B HestonDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Philip S InselDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.
Shea J AndrewsDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-1921-9470

Funding

RL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Yorghos Tripodis · 2021 to 2026
$25.6M
The Disadvantage Exposome as a Driver of Alzheimer’s Disease PathologyK00AG097172 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Margo Heston · 2025 to 2026
$169k
NIA NIH HHS K00 AG097172NIA NIH HHS P30 AG072978
6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) pathology accumulates decades before symptom onset, yet how the cumulative effect of genetic, familial, and modifiable lifestyle risk burden jointly affects plasma biomarker levels and trajectories in cognitively unimpaired older adults remains unknown. Methods: We analyzed data from 261 participants in the PREVENT-AD cohort. A composite risk score integrating Results: Discussion: Cumulative AD risk burden is broadly associated with plasma biomarker levels and specifically predicts accelerated ptau

Indexed as

cognitively unimpairedcomposite risk burdengeneticsplasma biomarkerspreclinicalrisk stratification

Identifiers

PMID42369495
PMCPMC13308081

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.