Evidence map›Paper›PMID 42369459›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Fanconi Anemia as a Window into Premalignant Field Cancerization of the Oral Mucosa.

Tamar Berger, Frank X Donovan, Yu-Chien Lin, Shivatheja Soma, Francis May, Kinjal Bhadresha, Christine Krieg, Neelam Giri, Lisa J McReynolds, Armando Filie and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tamar BergerLaboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA.
Frank X DonovanGenomics Core, Office of Scientific Core Facilities, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Yu-Chien LinLaboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA.
Shivatheja SomaCancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Francis MayLaboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA.
Kinjal BhadreshaCancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Christine KriegFanconi-Anämie Hilfe e.V, Eschau, Germany.
Neelam GiriClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Lisa J McReynoldsClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Armando FilieCytopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Zohreh KhavandgarNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Denise M LarondeDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
Martial GuillaudDepartment of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
Sharon A SavageClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6006-0740
David I KutlerDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, NY, USA.
Wayne CrismaniDNA Repair & Recombination Laboratory, St Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.ORCID 0000-0003-0143-8293
Eunike VelleuerInstitute for Pathology, Department for Cytopathology, Heinrich-Heine University of Düsseldorf, Germany.ORCID 0000-0003-4328-9556
Rachel UppgaardDepartment of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.
Ursula L HarperGenomics Core, Office of Scientific Core Facilities, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
K Olivia AlstonCancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
James W ThomasNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Arleen D AuerbachHuman Genetics and Hematology Program, The Rockefeller University, New York, NY, USA.
Settara C ChandrasekharappaGenomics Core, Office of Scientific Core Facilities, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Agata SmogorzewskaLaboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-6285-1562

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
NCATS NIH HHS UL1 TR001866
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) evolves through stepwise clonal expansion within genetically altered mucosa fields, yet actionable biomarkers remain undefined. Leveraging Fanconi anemia (FA), a cancer predisposition syndrome with extreme HNSCC risk due to defective DNA interstrand crosslink repair, we profiled premalignant changes in the oral cavity using noninvasive brush biopsies. Consistent with our prior demonstration of genomic instability in FA-associated SCCs, we detected pathogenic Statement of significance: Oral mucosa of individuals with Fanconi anemia contains frequent abnormal clones creating a premalignant field that increases cancer risk. The noninvasive brush sampling approach allows repeated measurements, ongoing surveillance, and assessment of prophylactic strategies that may be useful in the prevention of cancers in people with FA and in the general population. Somatic reversion of a pathogenic FANC variant may protect the oral mucosa from DNA repair deficiency and premalignant clonal evolution.

Identifiers

PMID42369459
PMCPMC13308307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.