ArticleGlobal pediatrics2026
Higher-volume breastmilk to improve growth among preterm infants in Zambia: A randomized clinical trial.
Article in Global pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Objective: To test the hypothesis that among very preterm infants, higher-volume feeding versus usual-volume feeding with exclusive breastmilk improves growth at 40-weeks' postmenstrual age (PMA). Design/Methods: We conducted a randomized controlled trial among preterm infants 28 0/7 to 31 6/7 weeks' gestation or weighing 1000-1999 g at birth admitted to the Kangaroo Mother Care Ward at the Women and Newborn Hospital, Lusaka, Zambia between June 2022 and February 2023. Study participants were randomized with a 1:1 parallel allocation to usual-volume breastmilk (140-180 ml/kg/day) or higher-volume breastmilk (200-240 ml/kg/day) achieved with additional breastmilk expression. Daily measurements of feeding volume were recorded until discharge. Following hospital discharge, study participants were assessed at 40-weeks' postmenstrual age for weight, length, mid-arm circumference, and head circumference. The primary outcome was growth velocity from enrolment to 40-weeks' postmenstrual age. Results: 190 preterm infants were enrolled. The mean±standard deviation (SD) number of days from enrollment to discharge was 9 ± 4 days. Recorded breastmilk volumes during hospitalization differed between groups (239 ±47 mL/kg/day in higher-volume versus 189±84 mL/kg/day in usual-volume; Conclusions: Higher-volume exclusive breastmilk feeding with breastmilk expression is feasible but did not improve growth velocity at 40-weeks' postmenstrual age in very preterm infants.
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