ArticleNAM journal2025
Assessment of the toxic effects of parabens, commonly used preservatives in cosmetics, and their halogenated by-products on human skin and endothelial cells.
Article in NAM journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives.Biomolecules · 2026Review
- Facile synthesis of Zn-Mn bimetallic MOF for adsorptive removal of methyl paraben from aqueous solution.Environmental science and pollution research international · 2026Article
- Parabens at Environmental Levels Modulate Virulence and Antimicrobial Tolerance of Exposed Biofilm Cells.Antibiotics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parabens, widely used as preservatives in cosmetics, are increasingly concerning due to potential health risks, while their chlorinated and brominated by-products, found in aquatic environments, pose additional toxicity concerns. This study evaluated the toxic effects of parabens, their metabolite, and three halogenated by-products on human skin and endothelial cells using cytotoxicity and wound healing assays. Human epidermal keratinocytes (HEK001) and human dermal microvascular endothelial cells (HMEC-1) were used as models. In keratinocytes, butylparaben (BuP) and benzylparaben (BeP) were the most cytotoxic, with EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.