Trial reportDrug design, development and therapy2026
Enhanced Recovery and Postoperative Analgesia After Laparoscopic Myomectomy: A Randomized Controlled Trial Comparing Total Intravenous Anesthesia, Transversus Abdominis Plane Block with Rectus Sheath Block, and Quadratus Lumborum Block.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study compares the effects of total intravenous anesthesia (TIVA, Group A), general anesthesia combined with transversus abdominis plane block and rectus sheath block (TAPB+RSB, Group B), and general anesthesia combined with quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL, Group C) on postoperative pain and recovery in patients undergoing laparoscopic myomectomy. Methods: This was a prospective, single-center, randomized controlled trial involving 120 patients (1:1:1 randomization). The primary outcome was the visual analog scale (VAS) score for oxytocin-induced uterine contraction pain at 24 hours postoperatively (T16). Secondary outcomes included postoperative analgesic efficacy, intraoperative anesthetic consumption, hemodynamics, recovery indicators, and adverse reactions. Results: Group C exhibited significantly lower oxytocin-induced contraction VAS scores than Groups B and A, with Group B also lower than A (all P<0.05). Postoperatively, Group C had the lowest resting/exercise VAS scores, analgesic pump presses, and rescue analgesia needs within 48 hours (P<0.05). Intraoperatively, Group C required the least propofol, remifentanil, and sufentanil, demonstrated superior hemodynamic stability, faster recovery/extubation, shorter PACU stays, better muscle strength, and higher QoR-15 scores (all P<0.05). PONV incidence was lower in Group C than A (P<0.05). No significant differences were found in patient demographics, operative/hospitalization time, or sleep quality, and no major block-related complications occurred. Conclusion: General anesthesia combined with QLB-LSAL can effectively alleviate postoperative uterine contraction pain, reduce the need for anesthetic drugs during and after surgery, promote early recovery, and does not increase the risk of complications, making it an optimized anesthesia protocol for laparoscopic myomectomy.
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