ArticleFrontiers in neurology
Resting-state functional connectivity and local activity differences across bothersome and non-bothersome tinnitus phenotypes.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to characterize resting-state functional differences across clinically defined bothersome tinnitus, non-bothersome tinnitus, and hospital-based non-tinnitus control groups, focusing on imaging differences related to tinnitus phenotype. Methods: This case-control study included 61 patients with bothersome tinnitus (BT), 52 with non-bothersome tinnitus (NBT), and 50 hospital-based non-tinnitus controls. Resting-state fMRI scans were acquired, and the data were analyzed using fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and seed-based functional connectivity (FC) using broad bilateral temporal lobe regions of interest to assess temporal-related network connectivity, including temporal-limbic interactions. Group comparisons were performed using ANCOVA controlling for demographic, audiological, physiological, sleep-related, and emotional covariates, cluster-level FDR-corrected Results: Resting-state fMRI revealed significant group differences in functional connectivity between the bilateral temporal lobe seed and the left ACC/mOFC cluster. Conclusion: Resting-state FC, fALFF, and ReHo measures revealed phenotype-related functional differences between BT and NBT. Because several key measures did not differ between BT and hospital-based non-tinnitus controls, these findings should be interpreted as group-level imaging features across tinnitus phenotypes, not as BT-specific abnormalities.
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