ArticleFrontiers in neurology
Ultra-early neurological pupil index trajectories and clinical outcomes in acute brain injury.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: To investigate the association between ultra-early quantitative pupillometry indices measured within the first 24 h of emergency department (ED) arrival and clinical outcomes in patients with acute brain injury. Methods: This retrospective analysis of a prospectively collected database assessed patients admitted to the ICU of a tertiary hospital for acute brain injury (aneurysmal subarachnoid hemorrhage, traumatic brain injury, intracerebral hemorrhage, and ischemic stroke) between September 2022 and July 2024. Automated pupillometry was performed at 0, 1, 3, 6, and 24 h after ED arrival. Neurological pupil index (NPi) trajectories were categorized into four clusters ( Results: Among 168 patients [age 69.6 ± 15.2 years; arrival GCS 7 (5-9); onset-to-arrival time 1.6 (0.9-5.2) h], ICU mortality was 29.8%. The Conclusion: Ultra-early changes in pupillometry indices during the hyperacute phase enhance risk stratification and improve outcome prediction in acute brain injury.
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