ArticleJournal of the Endocrine Society2026
Placental abundances of IGF1, IGF2, IGFBP2, IGF2R, and PPARα are associated with birth weight.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Context: The insulin/insulin-like growth factor (IGF) system is a key regulator of fetal growth and placental nutrient regulation. Objective: The objective of this study was to investigate associated gene and protein expressions of the insulin/IGF, adiponectin, and peroxisome proliferator-activated receptor (PPAR) pathways in placenta and cord blood from small-, appropriate-, or large-for-gestational-age (SGA, AGA, LGA) infants and corresponding first-trimester maternal blood. Methods: A total of 60 SGA, 109 AGA, and 55 LGA term infants (birth weight z scores <-2, -2 to +2, and >2, respectively) were included. Placental mRNA expression of 22 genes was analyzed using RT-qPCR. Immunohistochemistry (IHC) was used to determine the protein localization and abundance of 5 differentially expressed genes in 78 representative placental samples. Cord blood and maternal blood concentrations of related proteins were analyzed by ELISA. Results: Placental gene expression of Conclusion: Placental IGF1, IGF2, and PPARα signaling are positively associated with birth weight, whereas that of IGFBP2 is negatively associated, possibly reflecting a shared upstream regulation by nutrition. Conversely, placental IGF2R signaling may aid in normalizing abnormal fetal growth.
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