ReviewSAGE open medicine2026
Link between physical activity, nutrition, and antimicrobial pharmacokinetics and therapeutic efficacy: Implications for resistance management.
Review in SAGE open medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance (AMR) is a critical global health challenge, as it reduces the effectiveness of current therapies and demands novel integrative approaches. This narrative, integrative review analyzes how physical activity and nutrition interact with the pharmacological design of antimicrobial agents, influencing their absorption, metabolism, distribution, efficacy, and resistance development, drawing on studies published between 2015 and 2025 across microbiology, pharmacology, nutrition, and exercise physiology. Available evidence indicates that physical activity enhances immune competence, modifies pharmacokinetics, and promotes microbiome diversity, whereas nutrition influences bioavailability, micronutrient support, and nutrient-drug interactions. Conditions such as obesity, malnutrition, and metabolic disorders can critically alter drug disposition and therapeutic outcomes. Nutraceuticals and functional foods may act synergistically with antimicrobials, although antagonistic effects can impair their absorption or potency, and lifestyle-driven modulation of the microbiota and host metabolism appears to play an important role in resistance pathways. Emerging strategies, including prodrugs, nanocarriers, and personalized dosing algorithms, have the potential to optimize therapy according to lifestyle and metabolic profiles. Overall, incorporating lifestyle determinants into antimicrobial research and stewardship may improve therapeutic efficacy, reduce resistance, support precision medicine, and position diet and physical activity as key modulators of infection management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.