Evidence map›Paper›PMID 42369215›Full record

ArticleSAGE open medicine2026

The effect of voluntary chronic alcohol consumption on Th1/Th2 cytokine signature during adolescence in Sprague-Dawley Rats.

Kutlwano Moeketsi, Bongani B Nkambule, Kennedy H Erlwanger, Xitsakiso E Mabasa, Muzi J Maseko, Tawanda M Nyambuya

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In one paragraph

Article in SAGE open medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kutlwano MoeketsiDepartment of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Bongani B NkambuleSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Kennedy H ErlwangerDepartment of Physiology, School of Biomedical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-8058-885X
Xitsakiso E MabasaDepartment of Physiology, School of Biomedical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-6005-2329
Muzi J MasekoDepartment of Physiology, School of Biomedical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tawanda M NyambuyaDepartment of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-3288-9524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic alcohol use is a global health concern with adverse effects on immune function, potentially altering the T-helper (Th)1/Th2 axis. This study modelled chronic alcohol consumption using Sprague-Dawley (SD) rats to determine whether chronic alcohol consumption during adolescence skews Th1/Th2 cytokine release. Methods: A two-bottle choice rat model was used for voluntary adolescent alcohol intake. Twenty ( Results: White blood cell and lymphocyte counts were elevated in the alcohol group, while platelet counts decreased ( Conclusion: Chronic voluntary alcohol consumption during adolescence does not skew the immune response towards Th1 or Th2 cytokine release. Instead, it is associated with an overall decrease in the levels of Th1/Th2 cytokines, thus suggesting the immune-suppressive effect of alcohol.

Indexed as

adolescencealcoholcytokinesethanolT-cellsTh1/Th2

Identifiers

PMID42369215
PMCPMC13305916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.