ArticleFrontiers in cellular and infection microbiology2026
NLPR as a predictor of poor prognosis in patients with severe fever with thrombocytopenia syndrome: a prospective longitudinal study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by high mortality and rapid clinical progression. This longitudinal study aimed to investigate the temporal changes in laboratory parameters and evaluate the prognostic value of hematology-derived systemic inflammatory indices in patients with SFTS. Methods: Altogether, 235 hospitalized patients with SFTS were prospectively enrolled between 2022 and 2024. Demographic, clinical, treatment, and outcome data were collected and reassessed. Hematological, liver, and kidney function parameters, and myocardial parameters were routinely measured on days 0, 3, 7, and 10 after admission. Time-points stepwise Cox proportional hazards regression and receiver operating characteristic (ROC) curve analyses were performed at each time point to evaluate predictive performance. Results: Of the 235 patients, 61 (26.0%) died of SFTS. The median age was 64.0 (IQR 54.0-71.0) years, and 93 (39.6%) were male. After adjusting for confounding factors, serum creatinine (HR 1.017 [95% CI 1.006-1.029], Conclusions: NLPR may serve as a simple and effective prognostic marker for SFTS. Albumin treatment may be associated with a lower risk of mortality in patients with a high NLPR.
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