ArticleFrontiers in cellular and infection microbiology2026
Río Negro virus (Venezuelan equine encephalitis virus complex) shows pathogenic potential in a permissive murine model.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Río Negro virus (RNV), an enzootic member of the Venezuelan equine encephalitis virus (VEEV) complex, has historically been regarded as avirulent based on studies in adult immunocompetent animals. However, its pathogenic potential under biologically relevant conditions has not been systematically examined. Here, we investigated RNV infection in infant C57BL/6 mice as a permissive developmental model. Infection resulted in a transient viremic phase followed by systemic dissemination, disruption of splenic immune architecture, and pronounced neuroinflammatory and neurodegenerative alterations in the central nervous system. Viral replication in brain tissue coincided with astrocyte activation and elevated pro-inflammatory cytokine levels, indicating the establishment of immunopathological processes. These findings demonstrate that RNV retains the capacity to induce systemic and neuroinvasive disease under conditions of developmental immune immaturity. Our study provides the first comprehensive
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.