SynthesisFrontiers in medicine2026
Comparative efficacy of different types of structured exercise interventions for idiopathic pulmonary fibrosis: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Exercise interventions have demonstrated favorable effects for patients with idiopathic pulmonary fibrosis, but the optimal exercise regimen remains unclear. To address this, we conducted a meta-analysis. Objective: Investigate the effects of different types of structured exercise interventions on patients with idiopathic pulmonary fibrosis and evaluate the quality of evidence for study outcomes using the GRADE system. Method: Search databases including PubMed, Embase, Web of Science, The Cochrane Library, and Scopus to collect randomized controlled trials (RCTs) on exercise interventions for idiopathic pulmonary fibrosis published from the inception of each database through December 2025. Analyses were performed using RevMan5.4.1and R4.4.2 software. Results: A total of 11 studies involving 503 patients were included. Meta-analysis results showed that exercise interventions significantly improved the 6-min walk distance (MD = 38.62 m, 95% CI: [25.72, 51.51], Conclusion: Structured exercise interventions, including mind-body integrated training, can improve exercise endurance, selected pulmonary function measures, quality of life, and dyspnea symptoms in patients with idiopathic pulmonary fibrosis, but No firm conclusion on overall safety could be drawn. However, the evidence strength for most outcomes remains limited due to the risk of bias and heterogeneity in existing studies. Future high-quality research is needed to further validate the long-term benefits of different exercise modalities. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251253143, CRD420251253143.
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