ArticleFrontiers in medicine2026
Amniotic membrane transplantation combined with cryotherapy vs. lamellar keratoplasty for medically refractory peripheral ulcerative keratitis: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Medically refractory peripheral ulcerative keratitis (PUK) is a severe condition requiring urgent surgery. This study compares the clinical outcomes of amniotic membrane transplantation (AMT) combined with cryotherapy vs. lamellar keratoplasty (LKP) for this high-risk group. Methods: This retrospective cohort study evaluated patients with refractory PUK who underwent either AMT or LKP with a 12-month follow-up. Outcome measures included ulcer healing rate, best-corrected visual acuity (BCVA), epithelialization time, and recurrence rate. Results: A total of 58 patients (58 eyes) were included (AMT: Conclusions: LKP provides superior long-term optical/structural restoration and a lower recurrence rate, making it the definitive treatment for refractory PUK. However, AMT matches LKP in primary healing and mid-term efficacy. Amid global donor shortages, AMT serves as an invaluable, safe bridging therapy to stabilize the ocular surface and manage acute inflammation before definitive keratoplasty.
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