ArticleJournal of hand surgery global online2026
Tenosynovial and Transverse Carpal Ligament Biopsy for Early Transthyretin Amyloidosis Cardiomyopathy Detection: A Systematic Review and African American Retrospective Cohort Study.
Article in Journal of hand surgery global online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Performing tenosynovial biopsy during carpal tunnel release (CTR) has emerged as a promising diagnostic tool for systemic transthyretin amyloidosis cardiomyopathy (ATTR-CM). Early detection is critical because therapies, such as Tafamidis, have been shown to significantly improve outcomes when initiated prior to heart failure. The Val122Ile mutation (V122I) of the transthyretin (TTR) gene causes hereditary ATTR amyloidosis (hATTR), is found almost exclusively in people of African descent, and is underdiagnosed. The importance of diagnostic feasibility of transverse carpal ligament (TCL) biopsy is critical in the African American population, who often have poorer outcomes from delayed treatment. Methods: We reviewed 22 studies published between 2017 and 2025 and conducted a retrospective cohort study of patients who underwent CTR at our institution between 2021 and 2025. Intraoperative TCL or A1 pulley specimens were routinely biopsied. All samples were analyzed for the presence of amyloid using Congo Red staining. Demographic data were extracted from the medical record. Results: Our literature review found that 10% to 30% of CTR specimens contained amyloid deposits, mass spectrometry was the superior analytic modality, and biopsying the TCL in high-risk patients had greater diagnostic yield. At our institution, 89 patients (61.8% African American and 38.2% Caucasian) underwent CTR with concurrent tenosynovial biopsy between 2021 and 2025. The mean age was 55.36 ± 12 years and 32.6% were men. All specimens were analyzed with Congo Red staining. Amyloid deposits were not identified in any specimens. Conclusions: Our negative findings with the largest studied African American population to date underscore the importance of further investigation to refine selection criteria, standardize sampling, and clarify the role of TCL biopsy in early detection of ATTR-CM. Type of study/level of evidence: Therapeutic III.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.