ArticleNAR genomics and bioinformatics2026
Distinct repeat architecture landscapes in the proteomes of protozoan parasites.
Article in NAR genomics and bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protozoan parasites cause major infectious diseases and pose persistent global health challenges, particularly the emergence of drug-resistant strains. Tandem repeats and other repetitive architectures are widespread in proteomes and have been implicated in host-parasite interactions, immune evasion, and antigenicity. However, repeat-containing proteins (RPs) exhibit highly diverse architectures that extend beyond simple motif reiteration, making their comprehensive and quantitative characterization challenging. In this study, we performed bioinformatics analysis of repeat architectures in protozoan proteins. In addition to the established repeat-detection approaches, we developed a new algorithm, Drepper, which quantifies repeat-architecture complexity. By integrating diverse repeat-related features, we clustered RPs across species and identified distinct groups associated with parasite lineages. Notably, we identified a high-complexity, repeat-rich (HCRR) cluster enriched in
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