Evidence map›Paper›PMID 42368977›Full record

ReviewCancer innovation2026

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy.

Katherine Yaacoub

Abstract readReview
In one paragraph

Review in Cancer innovation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Katherine YaacoubDepartment of Sciences, Faculty of Natural and Applied Sciences Notre Dame University-Louaize Zouk Mosbeh Lebanon.ORCID https://orcid.org/0000-0001-7743-0592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When cells are unable to maintain their proper functions, they go into "Cell Death", either "Accidental" which is uncontrolled, or "Regulated" which is programmed and involves signaling cascades of specific molecules. Any perturbation of the cell death pathways is correlated with a large range of diseases including cancers. These irregularities in cell death mechanisms could however be used as therapeutic targets for a wide range of tumor indications. One of these strategies describes as "Cancer Immunotherapy" is using the power of the immune system to destroy cancer cells. A specific branch of Immunotherapy is "Immunogenic Cell Death" (ICD) which enhances tumor immunogenicity through regulated cancer cell death and triggers tumor-specific adaptive immune responses. A better understanding of ICD is critical for getting better anti-cancer modalities. This review focuses on ICD mechanisms, highlights the capacity of drugs to induce ICD, and discusses the importance of combining "ICD-inducers" with other strategies to enhance their efficiency.

Indexed as

cell deathcombination therapiesimmune checkpoint inhibitorsimmunogenic cell deathimmunotherapy

Identifiers

PMID42368977
PMCPMC13296833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.