SynthesisFrontiers in public health2026
Risk factors for nosocomial infections in ECMO patients: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nosocomial infection (NSI) is a serious complication in extracorporeal membrane oxygenation (ECMO) patients, yet reported risk factors remain inconsistent. A systematic synthesis is needed to identify key predictors. Methods: Following PRISMA guidelines, this meta-analysis (PROSPERO: CRD420251161290) searched five databases for studies reporting multivariate risk factors for NSI in adult ECMO patients. Study selection, data extraction, and quality assessment (Newcastle-Ottawa Scale) were performed independently by two reviewers. Pooled odds ratios (ORs) were calculated with random-effects models; heterogeneity (I Results: Thirty-four observational studies (≈8,901 patients) were included. Significant risk factors were: immunosuppression (OR 2.21, 95% CI 1.27-3.85), inter-hospital transport (2.24, 1.04-4.80), pre-ECMO infection (2.54, 2.03-3.18), higher SOFA score (per point: 1.13, 1.03-1.24), prolonged ECMO duration (per day: 1.10, 1.07-1.14), continuous renal replacement therapy (2.18, 1.57-3.02), and catheter intubation (1.24, 1.02-1.51). ECMO duration showed high heterogeneity (I Conclusion: NSI in ECMO patients arises from an interplay of baseline characteristics, illness severity, and invasive support duration/intensity. A stratified, risk-factor-based prevention strategy is warranted. Given the predominantly retrospective evidence, prospective studies are required for validation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251161290, Identifier: CRD420251161290.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.