ArticleInternational journal of endocrinology2026
Causal Association Between Thyroid Function and Myeloproliferative Disease: A Two-Sample Mendelian Randomization Study.
Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Causal Association Between Thyroid Function and Myeloproliferative Disease: A Two-Sample Mendelian Randomization Study.International journal of endocrinology · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Thyroid dysfunction has been linked to hematologic abnormalities, but whether thyroid function has a causal role in myeloproliferative diseases (MDs), including chronic myeloproliferative disease (CMD), remains unclear. We used Mendelian randomization (MR) to assess the potential causal effects of thyroid-related traits on MD risk. Methods: A two-sample MR analysis was performed using genome-wide association study (GWAS) summary statistics. Outcome data for CMD and MD, excluding chronic myelogenous leukemia (CML), were obtained from the Finnish R12 cohort (European ancestry). Genetic instruments for thyroid traits-including thyrotropin (TSH), free thyroxine (FT4), free/total triiodothyronine (FT3/TT3), FT3/FT4 and TT3/FT4 ratios, high/low TSH, and genetic liability to hyperthyroidism and hypothyroidism-were selected at genome-wide significance ( Results: Most thyroid function measures (TSH, FT4, FT3, TT3, hormone ratios, and hypothyroidism) showed no evidence of a causal association with CMD or MD excluding CML (IVW Conclusions: In this MR study, we found no robust evidence for a causal association between most genetically predicted thyroid function traits and MD after multiple-testing correction. The nominal signals observed for hyperthyroidism were phenotype-dependent and statistically unstable, particularly for self-reported CMD. These results emphasize that previously observed associations may be driven by nongenetic factors or clinical confounding.Jingjing Xiang and Jun Yan were co-first authors.
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