ArticleFrontiers in cardiovascular medicine2026
Association between NT-pro-BNP levels and endothelial dysfunction assessed by digital thermal monitoring in patients with coronary artery disease.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Endothelial dysfunction is a key mechanism in the progression of coronary artery disease (CAD). N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), a biomarker of myocardial wall stress, has been associated with vascular abnormalities beyond overt heart failure. However, its relationship with endothelial function, as assessed via digital thermal monitoring (DTM), in patients with CAD remains unclear. Methods: We conducted a cross-sectional study including 136 patients with angiographically confirmed CAD, in whom endothelial function was evaluated using the DTM-derived vascular reactivity index (VRI). VRI values of >2.0, 1.0-1.9, and <1.0 indicated good, intermediate, and poor vascular reactivity, respectively. A commercially available electrochemiluminescence immunoassay kit was used to examine serum NT-pro-BNP levels. Results: Vascular reactivity categorized based on DTM-derived VRI was poor in 8.8% ( Conclusions: In patients with CAD, high serum NT-pro-BNP levels were independently correlated with reduced VRI. Hence, NT-pro-BNP is independently associated with vascular reactivity dysfunction.
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