Evidence map›Paper›PMID 42368749›Full record

ArticleFrontiers in behavioral neuroscience2026

Transcranial alternating current stimulation improves cognitive functions in healthy subjects through modifying frontoparietal and dorsal attention networks based on personalized individual theta frequency analysis.

Burak Yulug, Ali Yalcinkaya, Ayse Karakuş, Shair Shah Safa, Dila Sayman, Alexandra Berekelia, Seyda Cankaya, Ceyhun Sayman, Sevilay Ayyildiz, Behçet Ayyildiz and 4 more

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Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Burak YulugDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Ali Yalcinkaya *Department of Neurology, Istanbul Medipol University, Istanbul, Türkiye.
Ayse Karakuş *Department of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Shair Shah Safa *Department of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Dila Sayman *Department of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Alexandra BerekeliaDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Seyda CankayaDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Ceyhun SaymanDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Sevilay AyyildizSchool of Medicine and Health, TUM-NIC Neuroimaging Center, Technical University of Munich, Munich, Germany.
Behçet AyyildizDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Türkiye.
Mehmet OzansoyDepartment of Physiology, International School of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Halil Aziz VeliogluDepartment of Neuroradiology, Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Lutfu HanogluDepartment of Neurology, Istanbul Medipol University, Istanbul, Türkiye.
Adil MardinogluScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Transcranial alternating current stimulation (tACS) has emerged as a promising tool to modulate cognitive functions by entraining endogenous neural oscillations. This study investigated the behavioral and neurophysiological after-effects of theta-frequency tACS individualized to each participant's intrinsic theta frequency (ITF). Methods: Twenty-two healthy participants were randomly assigned to either a real stimulation group (tACS group) or a sham group. Cognitive assessments and resting-state EEG/fMRI data were collected pre- and post-stimulation. Results: Participants in the real tACS group showed significant post-stimulation improvements in short-term memory, verbal fluency and category fluency scores compared to the sham group. Functional connectivity analyses revealed increased activity in the dorsal attention and frontoparietal networks only in the stimulation group, suggesting network-specific modulation. Discussion: These effects align with the theta-gamma coupling theory and provide evidence for long-lasting neuroplastic changes following personalized tACS. This study contributes to our understanding of brain stimulation and supports the use of tACS for cognitive enhancement in healthy individuals.

Indexed as

cognitive functiondorsal attention networkEEGfMRIfrontoparietal networkmemory enhancementtranscranial alternating current stimulation (tACS)

Identifiers

PMID42368749
PMCPMC13303487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.