Evidence map›Paper›PMID 42368711›Full record

ArticleMaterials today. Bio2026

Ultrasound-driven microbubble motors for targeted myocardial ischemia-reperfusion injury treatment.

Mingyuan Xu, Jiaxin Shan, Haichao Yang, Jiaxu Wang, Haobo Yang, Jinhong Liu, Jianfeng Chen, Dandan Yu, Tiecheng Zhang, Meng Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingyuan XuDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Jiaxin ShanDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Haichao YangUltrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
Jiaxu WangUltrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
Haobo YangDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Jinhong LiuDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Jianfeng ChenLaboratory Animal Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Dandan YuDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Tiecheng ZhangDepartment of Magnetic Resonance Diagnosis, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Meng YangDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Wei ZhangDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zhuo WangDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Xiaoping LengDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia-reperfusion injury (MIRI) is a secondary pathological process that occurs after restoration of blood flow during the treatment of acute myocardial infarction. The effective prevention of MIRI is pivotal for optimizing therapeutic efficacy and improving long-term patient outcomes. In this study, we developed an ultrasound-driven, multilevel targeted bionic microbubble motor (CsA@NM-MBs motors) that can break through the vascular endothelial and cell membrane barriers to achieve precise, targeted drug delivery. The CsA@NM-MBs motors were coated with a neutrophil membrane, a highly biocompatible membrane with natural inflammatory targeting abilities, enabling active homing to damaged areas. Upon application of an external ultrasound field, the CsA@NM-MBs motors actively crossed the vascular endothelial barrier and reached the myocardial tissue in the MIRI area with precision. With the aid of ultrasound-targeted microbubble destruction (UTMD) technology, acoustic pores are formed on the cell membrane, enabling it to break through the cell barrier. The driving force generated by the explosion enables CsA to be delivered into cells, thereby achieving safe and efficient drug release. This ultrasound-driven cell membrane biomimetic multilevel targeting strategy significantly enhanced the enrichment and delivery efficiency of CsA at the injury site, providing a new approach for the treatment of MIRI.

Indexed as

Cyclosporine AMobile micro-/nano motorsMyocardial ischemia-reperfusion injuryNeutrophil membrane biomimicryUltrasound-driven

Identifiers

PMID42368711
PMCPMC13293769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.