Evidence map›Paper›PMID 42368710›Full record

ArticleMaterials today. Bio2026

Mild photothermal therapy ameliorates neurogenic bladder after sacral spinal cord injury via multi-target effects.

Kaiping Bai, Susu Guo, Junxiang Wen, Jiajie Zhang, Xiaoling Huang, Fei Yuan, Yanping Hou, Pengtao Liu, Zeyu Xiao, Kai Cui and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaiping BaiDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Susu GuoDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, 200030, China.
Junxiang WenDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Jiajie ZhangDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Xiaoling HuangDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Fei YuanDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Yanping HouDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Pengtao LiuDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.
Zeyu XiaoDepartment of Pharmacology and Chemical Biology, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Kai CuiDepartment of Pharmacology and Chemical Biology, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Jie SunDepartment of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai, 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurogenic bladder (NB) is a devastating complication following sacral spinal cord injury (SSCI), often leading to urinary incontinence, recurrent infections, and progressive renal dysfunction, which severely impair patients' quality of life and survival. Current therapeutic options remain largely palliative and fail to reverse the underlying neurogenic pathology. This study employed mild photothermal therapy (MPTT) to treat SSCI-induced NB in rats and systematically investigated its efficacy and mechanisms. Results showed that MPTT effectively improved bladder morphology and urodynamic parameters, with more significant effects observed in early intervention. Mechanistically, MPTT inhibited bladder fibrosis, alleviated chronic inflammation, restored the balance between cell proliferation and apoptosis, promoted functional angiogenesis, and repaired structural damage and function of bladder nerve fibers. MPTT ameliorates SSCI-NB function through multi-target effects, and its time-dependent therapeutic efficacy suggests the necessity of early and repeated interventions, providing experimental and theoretical evidence for new NB treatment strategies.

Indexed as

Neurogenic bladderPhotothermal therapySacral spinal cord injurySelf-stacked small moleculesVoiding function

Identifiers

PMID42368710
PMCPMC13293753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.