ReviewBrain & spine2026
Research trends and hotspots in Adipose-Derived Stem Cell applications for peripheral nerve regeneration from 2000 to 2025: a bibliometrics visualization study.
Review in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Peripheral nerve injuries (PNIs) cause significant disability. Autologous nerve grafts remain the gold standard but are limited by donor-site morbidity, restricted graft availability, and inconsistent functional recovery. Adipose-derived stem cells (ADSCs) have emerged as promising adjuncts due to their accessibility and regenerative potential. Research question: How has global research on ADSCs in peripheral nerve repair evolved, and what are the leading contributors, dominant themes, and emerging trends? Material and methods: A bibliometric analysis was performed using the Web of Science Core Collection for studies published from January 2000 to September 2025. Predefined search terms for ADSCs and peripheral nerve repair were applied. VOSviewer (v1.6.20) and CiteSpace (v6.3.R1 Advanced) were used to build co-authorship, co-citation, and keyword co-occurrence networks and to assess thematic evolution. Results: The final dataset comprised 555 articles authored by 2750 researchers from 54 countries and 849 institutions, citing 16,466 references. Global output increased consistently after 2011, with a peak in 2019. When adjusted for population size, Switzerland showed the highest research intensity (3.22 publications per million inhabitants), followed by Sweden (1.81), Belgium (1.12), and Austria (1.11). Countries with the highest absolute output, including the United States (0.32) and China (0.12), demonstrated lower per capita contributions. Seminal work by Kingham and Coleman formed the conceptual basis for ADSC-mediated nerve regeneration. Keyword analysis revealed a shift from structural tissue engineering toward paracrine signaling, exosome-based strategies, and translational approaches. Discussion and conclusion: ADSCs are central to regenerative strategies for PNIs. Despite strong preclinical evidence, clinical translation remains limited, highlighting the need for standardized protocols and robust clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.