Evidence map›Paper›PMID 42368604›Full record

ArticleEULAR rheumatology open2025

On the edge of dependency: how older adults with rheumatoid arthritis experience living with frailty.

Signe Marie Abild, Julie Midtgaard, Charlotte Werdal Hansen, Luise Holberg Lindgren, Pernille Fevejle Cromhout, Katrine Storm Piper, Bente Glintborg, Tanja Thomsen, Mathilde Glud Christensen, Bente Appel Esbensen

Abstract read
In one paragraph

Article in EULAR rheumatology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Signe Marie AbildRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.
Julie MidtgaardCopenhagen University Hospital-Mental Health Services, Mental Health Center Glostrup, Centre for Applied Research in Mental Health Care (CARMEN), Glostrup, Denmark.
Charlotte Werdal HansenRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.
Luise Holberg LindgrenRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.
Pernille Fevejle CromhoutNovo Nordisk A/S, Søborg, Denmark.
Katrine Storm PiperDepartment of Occupational Therapy and Physiotherapy, Copenhagen University Hospital, Copenhagen, Denmark.
Bente GlintborgRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.
Tanja ThomsenRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.
Mathilde Glud ChristensenGeriatric Medicine, Zealand University Hospital Koge, Koge, Denmark.
Bente Appel EsbensenRigshospitalet, Center for Rheumatology and Spine Diseases, Center for Arthritis Research (COPECARE), Glostrup, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Up to one third of people with rheumatoid arthritis (RA) are frail, facing increased vulnerability, comorbidities, and psychological challenges. As people with RA live longer, frailty becomes increasingly relevant to clinical care. This study explores how individuals aged ≥65 years with RA experience frailty and how it affects their daily lives and health management. Methods: We conducted an explorative qualitative interview study using purposeful sampling. Participants were recruited from a rheumatology outpatient clinic. Inclusion criteria were age ≥65 years, RA diagnosis, a Multidimensional Health Assessment Questionnaire score >1, and a frailty score, assessed using the Clinical Frailty Scale (CFS), of 4 to 7 (living with very mild frailty to severely frail). We aimed for variation in age, sex, and frailty. The individual semistructured interviews were analysed using reflexive thematic analysis. Results: Seventeen participants (10 women, mean age 75 years) were included: 4 living with very mild frailty (CFS score 4), 6 mildly frail (CFS score 5), and 7 moderately frail (CFS score 5). The following 3 themes were developed: (1) 'When frailty distorts the life, you once knew', highlighting the emotional toll of facing physical decline, (2) 'The hard shared burden of frailty', exploring the relational dynamics of frailty, and (3) 'Navigating frailty and RA-balancing unmet needs', emphasising the challenges of balancing autonomy and support. Conclusions: The experience of frailty profoundly shapes the experience of ageing with RA, complicating self-management and challenging both identity and relationships. These findings highlight the need for healthcare systems across sectors to address frailty holistically, supporting both physical and psychosocial needs through coordinated care.

Identifiers

PMID42368604
PMCPMC13292405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.