Evidence map›Paper›PMID 42368583›Full record

ArticleActa pharmaceutica Sinica. B2026

Steroid hormone ouabain cooperates with Na

Lili Chen, Kuida Chen, RunRun Shan, Jinjun Bian, PeiPei Jin, Hao Lin, Jian Liu, Yan Chen, Siyao Zhu, Fangzhou Yin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lili ChenState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Kuida ChenState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
RunRun ShanState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Jinjun BianFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
PeiPei JinFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Hao LinState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Jian LiuState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Yan ChenState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Siyao ZhuHarvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Fangzhou YinSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wu YinState Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic reprogramming underpins trained immunity (TRIM). However, the importance of mRNA reprogramming in TRIM remains unknown. Here, we discovered, for the first time, that the steroid hormone ouabain creates a significant training effect on peripheral innate immune cells (IICs), leading to functional enhancement of IICs against bacterial infections. However, unlike conventional training mechanisms, ouabain primarily relies on an integrated posttranscriptional RNA regulon complex (IPRRC) to establish immune memory and reprogram cytokine expression, with lncRNA-CYTOR playing a critical role in this process. Moreover, to enhance training effects while reducing lactate production, ouabain promotes a rapid degradation of the Na

Indexed as

CYTOREndotoxin toleranceImmune trainingInnate immune cellsmRNA reprogrammingNa+,K+-ATPasePosttranscriptional RNA regulonsSteroid hormone ouabain

Identifiers

PMID42368583
PMCPMC13305168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.