ArticleDEN open2027
Efficacy of Endoscopic Ultrasound-guided Fine Needle Biopsy With Simplified Macroscopic On-site Evaluation (With Video).
Article in DEN open, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: With advances in preoperative chemotherapy and comprehensive genomic profiling, endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) has become vital for diagnosing pancreatic and peridigestive tract lesions. However, evidence remains limited regarding the performance of new-generation puncture needles and simplified specimen evaluation methods. This study retrospectively assessed the diagnostic ability and procedural adverse events (AEs) of a new-generation puncture needle for solid pancreatic, subepithelial, and other lesions. Methods: We analyzed data from 1232 consecutive patients who underwent EUS-FNB between August 2016 and November 2023 at a single care center. Specimen processing was performed using the simplified macroscopic on-site evaluation (S-MOSE) method, which does not require additional pathological tests such as rapid on-site evaluation or cytology. Results: The overall diagnostic accuracy using S-MOSE was 93.7%. Specifically, the diagnostic accuracy for pancreatic cancer was 95.8%. The AE rate was 1.1% (14/1232), including pancreatitis (six), hemorrhage (five), hematoma (two), and pancreatic fistulas (one). The first puncture diagnostic rate was 83.6%, which increased to 92.5% after the second puncture, with only a marginal gain of 1.2% beyond the third puncture. Multivariable analysis identified smaller lesion size and benign pathology as factors associated with lower diagnostic accuracy; conversely, malignant pathology was associated with higher diagnostic accuracy (odds ratio 1.895, Conclusion: EUS-FNB with S-MOSE, typically requiring up to two punctures, provides efficient and accurate histopathological diagnosis across diverse lesions while minimizing procedural burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.